more articles link below
E.E.Bukatina, I.V.Grigoriyeva and O.R.Smirnov
European Neuropsychopharmacology – 1994. V.4, №3.
p.389
Tiapride was used in an open non-controlled study of 31 patients aged
54-88 (average age 70.1) with anxiety, excitement, delusion and hallucinations,
asthenic a negative symptoms of schizophrenia. Nineteen patients suffered from
schizophrenia, two from circular psychosis, and 10 from dementias of old age. The
daily dose of tiapride was 01.-0.6, and duration of therapy from 1 to 92 days,
on average 26.2 days.
Ten patients with schizophrenia with duration of disease of 13-41 years
had severe negative symptoms that were observed during 8-20 years. Against the background of treatment with
tiapride five of them were observed to have a decrease of autism, aspontaneity
and inadequacy. With two patients with
extremely severe negative symptoms the improvement was noted on days 5 and 6 of
treatment and showed in that the patients began to fix their eyes on the
interviewer, answer questions, and display some interest in the conversation.
Afterwards one of them began to talk a little about himself, came for medicine without
assistance. In three other milder cases the therapeutic effect was more obvious.
The patient became more amiable, open, syntonous and sociable. Their behavior
became more adequate. They began to help
the staff and weak patients both in answer to corresponding requests and on
their own initiative. The first signs of improvement in these cases were
observed on days 9, 14 and 30 of therapy. These patients took tiapride not less
than 2 months and during the whole period of therapy a further extension of the
achieved effect was observed.
A positive effect of tiapride was found on asthenic symptoms and, as in
other studies, on hyperkinesis, especially oral ones up the full disappearance
of the latter.
Tiapride led to a severe intensification of alarm on the same or the
next day with all three patients that had these symptoms also intensification
of delusions, hallucinations and psychomotor excitation was noted. The latter appeared with a patient suffering from
schizophrenia, in which a decrease of profound negative symptoms took place,
causing the withdrawal of tiapride. Alarm, excitation, delusions and
hallucinations appeared also in patients in whom these symptoms were absent at
the beginning of therapy but had been there in the disease pattern earlier. The
state of the patients returned to the initial level after withdrawal of
tiapride.
Комментариев нет:
Отправить комментарий